Potassium Carbonate → HCID 19830855, compound

Participants

Reaction Conditions

Reaction Steps

5-Acetylamino-2-(3-chloropropyl)naphto[1,8-cd]isothiazole 1,1-dioxide (0.8 g), 4-phenyl-1,2,3,6-tetrahydropyridine (0.4 g), potassium carbonate (4 g) and acetonitrile (25 cc) are heated at boiling point for 20 hours. The reaction mixture is cooled to a temperature of about 20° C. The solution is filtered and then concentrated to dryness at 40° C. under reduced pressure (20 mm Hg; 2.7 kPa). The residue is purified by chromatography on silica column with a mixture of ethyl acetate and methylene chloride (70-30 vol) as eluant, then recrystallized from boiling ethanol (20 cc). 5-acetylamino-2-[3-(4-phenyl-1,2,3,6-tetrahydro-l-pyridyl)propyl]naphtho[1,8-cd]isothiazole 1,1-dioxide (0.35 g) is obtained, m.p. 178° C.

Provenance & Evidence