反应详情

温度

60 °C

A mixture of 6 % of 2-nitroimidazole (53 mmol) and 7.32 % of KzCO3 was heated at 60° C. for 0.5 hours. Then 8.6 % (53 mmol) of 3-(3-chloropropyl)-2-oxazolidinone (Ann. Pharm. Franc., 13, 565 (1955)) was added and stirring continued for 18 hours at 60° C. The mixture was then cooled and concentrated. The residue was partitioned between CHCl3 and water, the organic layer was dried and concentrated to give 10.4 g of a solid which was recrystallized from ethanol to provide 5.4 g (42%) of the desired product, 3-3-(2-nitro-1H-imidazol-1-yl)propyl]-2-oxazolidinone; mp 89°-91° C.

1. temperatureThe mixture was then cooled
2. concentrationconcentrated
3. customThe residue was partitioned between CHCl3 and water
4. customthe organic layer was dried
5. concentrationconcentrated