HuagongsheHuagongshe Chemistry Print Report · For research reference only
3-[2-(2-Nitro-1H-imidazol-1-yl)ethyl]-2-oxazolidinone → N-(2-Bromoethyl)-2-nitro-1H-imidazole-1-ethanamine, monohydrobromide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 3-[2-(2-Nitro-1H-imidazol-1-yl)ethyl]-2-oxazolidinone | HCID 14896626 | — |
| Reactant | Acetic Acid Mixture with Hydrobromic Acid | HCID 21893785 | — |
| Solvent | Methanol | HCID 887 | — |
| Solvent | Diethyl Ether | HCID 3283 | — |
| Product | N-(2-Bromoethyl)-2-nitro-1H-imidazole-1-ethanamine, monohydrobromide | HCID 14896628 | — |
Reaction Steps
To 3.5 g (15 mmol) of 3-[2-(2-nitro-1H-imidazol-1-yl)ethyl-2-oxazolidinone was added 30 ml of 31% HBr/acetic acid and the mixture was stirred for 18 hours at 20°-25° C. The mixture was diluted with ether and methanol and the resulting solid was collected. Recrystallization from ethanol/water gave 3.0 g of the desired product, N-(2-bromoethyl)-2-nitro-1H-imidazole-1-ethanamine, monohydrobromide (54%); mp 103°-104° C.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05036096 |
| Source dataset | uspto-grants-1991_07 |
| ORD ID | ord-f61f2793daca41619b5875abe6093803 |
| Source note | uspto-grants-1991_07 |