Water → 1-[3-(1-Ethoxyethoxy)-4,4,4-trifluorobutoxy]-4-nitrobenzene

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Reaction Steps

To a suspension of 2.4 g (0.049 mol) of 50% NaH in 50 ml of THF, is slowly added a solution of 10.6 g (0.049 mol) of 3-(1-ethoxyethoxy)-4,4,4-trifluoro-1-butanol in 15 ml of THF. When no more gas evolves, a solution of 6.5 g (0.041 mol) of 4-chloronitrobenzene in 65 ml of DMF is added. After 30 min., the reaction medium is poured on iced water. The reaction medium is extracted with ether. The organic phase is washed with water, dried over Na2SO4 and concentrated. The aimed product is obtained with a 78% yield after recrystallization from isopropanol. m.p.: 81° C.;

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