HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1087615Generated: October 25, 2026
Diethyl Ether → alpha-Bromo-2-chlorobenzeneacetic acid
https://huagongshe.com/reaction/1087615
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Diethyl Ether | HCID 3283 | — |
| Reactant | Bromoform | HCID 5558 | — |
| Reactant | 2-Chlorobenzaldehyde | HCID 6996 | — |
| Reactant | Potassium Hydroxide | HCID 14797 | — |
| Catalyst | Tetrabutylphosphonium bromide | HCID 76564 | — |
| Solvent | Water | HCID 962 | — |
| Product | alpha-Bromo-2-chlorobenzeneacetic acid | HCID 2774031 | — |
Reaction Steps
A solution of 141 g of (2-chloro)benzaldehye and 270 g of tribromomethane in 500 ml of ethyl ether is added to a solution of 270 g of potassium hydroxide and 34 g of tetrabutylphosphonium bromide in 800 ml of water. The mixture is stirred for 24 hours at 0° C.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| Patent number | US05036156 |
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| Source dataset | uspto-grants-1991_07 |
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| ORD ID | ord-0e981cbe0fba4a229bcde6faef4026e2 |
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| Source note | uspto-grants-1991_07 |
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