HCID 131716959, compound → HCID 15629285, compound

Participants

Reaction Steps

To 218 g (466 mmol) of allo-1-(4-toluenesulfonyl)- 4-(4-toluenesulfonyloxy)-D-proline ethyl ester in 1500 ml of toluene was added 81 g (606 mmol) of tetramethyl ammonium acetate and the mixture was heated to reflux for 2 hours. The reaction was cooled, washed with 2x500 ml of water and dried over sodium sulfate. Evaporation of the solvent and drying the resulting solids in a vacuum oven overnight at 30° C. provided 120.6 g of product (72% yield). M.P.=82°-83° C.

Provenance & Evidence