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Methyl Isocyanate → N-(4-benzyloxybenzyl)-O-methylcarbamoylacetohydroxamic acid
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Methyl Isocyanate | HCID 12228 | — |
| 反応物 | N-(4-benzyloxybenzyl)acetohydroxamic acid | HCID 129265 | — |
| 触媒 | 1,8-Diazabicyclo(5.4.0)undec-7-ene | HCID 81184 | — |
| 溶媒 | Tetrahydrofuran | HCID 8028 | — |
| 生成物 | N-(4-benzyloxybenzyl)-O-methylcarbamoylacetohydroxamic acid | HCID 15670601 | 82.6% |
反応手順
A mixture of N-(4-benzyloxybenzyl)acetohydroxamic acid (1.35 g), methyl isocyanate (0.65 g) and 1,8-diazabicyclo[5.4.0]undec-7-ene catalyst (1 drop) in tetrahydrofuran (10 ml) was stirred for 3 hours then left overnight to provide N-(4-benzyloxybenzyl)-O-methylcarbamoylacetohydroxamic acid (1.35 g) m.pt. 101°-102° [from ethyl acetate-light petroleum (b.pt. 60°-80°)].
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US05036157 |
| 出典データセット | uspto-grants-1991_07 |
| ORD ID | ord-a7f6db8958e24b228d335a3f5db664a9 |
| 出典メモ | uspto-grants-1991_07 |