HuagongsheHuagongshe Chemistry Print Report · For research reference only
Diethyl Ether → N-(4-Benzyloxybenzyl)-N-(t-butylcarbonyloxy)acetamide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Diethyl Ether | HCID 3283 | — |
| Reactant | Triethylamine | HCID 8471 | — |
| Reactant | Pivaloyl chloride | HCID 62493 | — |
| Reactant | N-(4-benzyloxybenzyl)acetohydroxamic acid | HCID 129265 | — |
| Solvent | Dichloromethane | HCID 6344 | — |
| Solvent | 2-Dimethylaminopyridine | HCID 21885 | — |
| Product | N-(4-Benzyloxybenzyl)-N-(t-butylcarbonyloxy)acetamide | HCID 19817263 | — |
Reaction Steps
Pivaloylchloride (1.36 ml) was added dropwise to a solution of N-(4-benzyloxybenzyl)acetohydroxamic acid (2.71 g) and triethylamine (1.7 ml) in methylene dichloride (15 ml) and dimethylaminopyridine (100 ml). The mixture was stirred for 2 hours at room temperature, then neutral material was isolated with ether. The product, N-(4-(Benzyloxybenzyl)-N-(t-butylcarbonyloxy)acetamide, was a colourless oil.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05036157 |
| Source dataset | uspto-grants-1991_07 |
| ORD ID | ord-dc3e59f89ed741099e8fc04c481bc66a |
| Source note | uspto-grants-1991_07 |