huagongshe.com
HRID1087676

反应详情

EQUATION

反应方程式

HRID 1087676 的结构方程式

REACTANTS

反应物

1
结构：C[C@]12CCC(=O)C=C1CC[C@H]1[C@@H]3CCC(=O)[C@@]3(C)CC[C@@]12O
HCID10425017

9α-hydroxyandrost-4-en-3,17-dione

C19H26O3

PRODUCTS

生成物

1
结构：C[C@]12CCC(=O)C=C1CC[C@@H]1C2=CC[C@]2(C)C(=O)CC[C@@H]12
HCID239595

9-Dehydroandrostenedione

C19H24O2

AUXILIARIES

试剂、催化剂与溶剂

1
结构：O=S(=O)(O)Cl
溶剂HCID24638

Chlorosulfuric acid

HClO3S

PROCEDURE

实验过程

Following the general procedure of Example 6 but making non-critical variations, 9α-hydroxyandrostenedione (20.00 g.) is reacted with chlorosulfonic acid (10 ml.) at a temperature of 20°-27° for 17 minutes. Upon workup the reaction gives androsta-4,9(11)-diene-3,17-dione, 15.9 l g., (79.5% weight yield, 84.4 % chemical yield); m.p. 200.5°-204°; [α]D +218° (chloroform); UV (methanol)λmax =240 nm (ε=15,200).