9alpha-Hydroxyandrost-4-ene-3,17-dione → 9-Dehydroandrostenedione

Participants

Reaction Steps

9α-Hydroxyandrostenedione (.302 g.) is stirred in methanesulfonic acid (3.0 ml.) at 25°. After 80 minutes the reaction is quenched by addition of water (15 ml.). The solids are stirred for 2 hours at 35°, collected, air-dried overnight to give androsta-4,9(11)-diene-3,17-dione, 0.272 g. (95.6% chemical yield).

Provenance & Evidence