Propargyl bromide → HCID 10039974, compound

Participants

Reaction Steps

The compound was synthezised from tert.butyl 3-hydroxy-5,6,7,8-tetrahydro-4H-isoxazolo [4,5-c]azepin-5-carboxylate (from Example 7) and 2-propynyl bromide, by the method described in Example 4. The title compound was isolated by using chromatography on silica gel (eluent: toluene-ethyl acetate (3:1)) in a yield of 58%. 1H NMR: δ4.83 (2 H, d), 4.20 (2 H, s), 3.60 (2 H, t), 2.83 (2 H, t), 2.52 (1 H, t), 1.86 (2 H, m), 1.43 (9 H, s).

Provenance & Evidence