Tetrahydrofuran → HCID 86744238, compound

Participants

Reaction Steps

To an ice cooled solution of ethyl 4-carboxyethyl-3-oxopiperidine-1-carboxylate ethylene ketal (38 g, 0.132 mol, U.S. Pat. No. 4,278,676) in tetrahydrofurane (100 ml) is added lithium aluminium hydride pellets (2.51 g, 0.066 mol). The ice bath is removed and the reaction mixture is allowed to reach reflux temperature and is then kept at reflux temperature for 3 hours. The mixture is quenched with dilute hydrochloric acid and is diluted with dichloromethane. The mixture is washed twice with saturated brine, dried over magnesium sulphate and evaporated in vacuo to give 27.3 g (0.111 mol, 84%) of oily title product.

Provenance & Evidence