Hydrochloric Acid → HCID 22163568, compound

Participants

Reaction Steps

To a solution of ethyl 4-methyl-3-oxopiperidine-1-carboxylate ethylene ketal (94 g, 0.41 mol) in tetrahydrofurane (200 ml) was added concentrated hydrochloric acid (200 ml), and the mixture was stirred for 16 hours at room temperature. Most of the tetrahydrofurane was evaporated in vacuo, and the residue was extracted with dichloromethane (3×200 ml). The organic phase was washed with saturated brine (2×150 ml), dried over magnesium sulphate and evaporated in vacuo to yield oily title product (60.1 g, 0.33 mol, 79%).

Provenance & Evidence