Sodium borohydride → HCID 23166913, compound

Participants

Reaction Steps

A stirred solution of ethyl (E)-7-{1-(4-fluorophenyl)-3-isopropylpyrrolo[2,1-a]phthalazin-2-yl}-5- hydroxy-3-oxohept-6-enoate (3.98 g) in methanol (120 ml) under an argon atmosphere at 0°-5° C. was treated with sodium borohydride (243 mg). After 3 hours the solution was allowed to warm to room temperature, and was then evaporated to small volume (20 ml). The solution was treated with water (300 ml), and extracted with a mixture of diethyl ether and ethyl acetate (2×250 ml; 1:1 v/v). The combined extracts were dried over magnesium sulphate and evaporated, to give methyl (E)-7-{1-(4-fluorophenyl)-3-isopropylpyrrolo[2,1-a]-phthalazin-2-yl}-3,5-dihydroxyhept-6-enoate, in the form of an orange foam (3.16 g).

Provenance & Evidence