Tetrafluoroboric acid → HCID 22163777, compound

Participants

Reaction Conditions

Reaction Steps

A stirred solution of 1-cyano-2-isobutyryl-1,2-dihydrophthalazine (12.6 g) in glacial acetic acid (50 ml) at 60° C. was treated with an aqueous solution of fluoroboric acid (48% w/v; 50 ml). After stirring for 15 minutes the mixture was chilled to 15° C. and stirring was continued for a further period of 1 hour. The solid which separated was collected, washed thoroughly with diethyl ether, and dried, to give 1-amino-3-isopropyloxazolo[4,3-a]phthalazinium tetrafluoroborate (15.58 g) in the form of a bright yellow solid, m.p. 180°-182° C. [NMR (in DMSO-d6) : 1.42 (6H, d, J=7 Hz), 3.74 (1H, septet, J=7 Hz), 7.50-7.60 (1H, m), 7.85-8.05 (3H, m), 8.12 (2H, broad singlet), 8.99 (1H, s)].

Provenance & Evidence