Triethylamine → HCID 14836227, compound

Participants

Reaction Steps

A mixture of 6.5 g of 3-(2-chloroethyl)oxazolidin-2-one, 4.57 g of 3-ethoxypropylamine and 10 g of triethylamine was refluxed for 10 hours, diluted with THF and water. The organic layer was worked up to give 5.13 g of 1-(3-ethoxypropyl)-3-(2-hydroxyethyl)imidazolidin-2-one, b.p. 110° C./0.5 mm. This material was methylated with 4.26 g of iodomethane and 1.13 g of NaH (60% in oil) in 60 ml of THF as mentioned under Example 22. This gave 3.9 g (71.4%) of oil, b.p. 100°-105° C./0.5 mm.

Provenance & Evidence