反应详情

To a solution of 28 g of 2-amino-3-(4-methoxybenzoyl)-5-hexylthiophene in 150 ml of chloroform is added 10 g of chloroacetyl chloride and the mixture is refluxed under heating with stirring for 2 hours. After cooling, the mixture is washed with 5% aqueous sodium hydrogencarbonate solution and sodium chloride solution, and dried over anhydrous magnesium sulfate. After separating by filtration, the filtrate is concentrated under reduced pressure and the residue is crystallized from ethanol to give 16.2 g of 2-chloroacetamido-3-(4-methoxybenzoyl)-5-hexylthiophene as crystals.

1. temperaturethe mixture is refluxed
2. temperatureunder heating
3. temperatureAfter cooling
4. washthe mixture is washed with 5% aqueous sodium hydrogencarbonate solution and sodium chloride solution
5. dry with materialdried over anhydrous magnesium sulfate
6. customAfter separating by filtration
7. concentrationthe filtrate is concentrated under reduced pressure
8. customthe residue is crystallized from ethanol