Chromic Acid → HCID 14369947, compound

HRID 1087771Notes

Reaction equation

HRID 1087771 reaction equation
[Cr](O)(O)(=O)=O.[Cl:6][C:7]1[CH:12]=[CH:11][C:10]([CH2:13][CH2:14][CH:15]([OH:24])[C:16]([CH3:23])([N:18]2[CH:22]=[CH:21][CH:20]=[N:19]2)[CH3:17])=[CH:9][CH:8]=1>O.C(O)(=O)C>[Cl:6][C:7]1[CH:8]=[CH:9][C:10]([CH2:13][CH2:14][C:15](=[O:24])[C:16]([CH3:17])([N:18]2[CH:22]=[CH:21][CH:20]=[N:19]2)[CH3:23])=[CH:11][CH:12]=1

Participants

5

Reactant 2

HCID 24425Chromic AcidHCID 14369946HCID 14369946, compound

Product 1

HCID 14369947HCID 14369947, compoundYield 94%

Reagents, catalysts & solvents 2

HCID 176Acetic AcidSolvent2×HCID 962WaterSolvent2×

Procedure

A solution of 6.4 g (0.064 mol) of chromic acid in 5 ml of water and 20 ml of glacial acetic acid is added dropwise at 5° C. to a solution of 23.5 g (0.085 mol) of 5-(4-chlorophenyl)-2-methyl-2-(pyrazol-1-yl) -pentan-3-ol in 60 ml of glacial acetic acid in the course of one hour. The mixture is subsequently stirred for a further 25 hours at room temperature. The mixture is stirred into 2,000 ml of water and extracted five times with 200 ml of methylene chloride each time, and the solvent is removed by distillation. 22.1 g (94% of theory) of 5-(4-chloro-phenyl)-2-methyl-2-(pyrazol-1-yl)-pentan-3-one of diffraction index n23D =1.5278 are obtained. ##STR23##

Workup

  1. extractionextracted five times with 200 ml of methylene chloride each time
  2. customthe solvent is removed by distillation

Sources & evidence

ORD record
ord-ec2315c896cb46ad9b808c34534a39e7
Source dataset
uspto-grants-1990_10
Patent number
US04960781

Reaction notes

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