5-Methyl-2-hexanone → 2-(7-Methyl-1,8-naphthyridin-2-yl)-3-(5-methyl-2-oxohexyl)-1-isoindolinone

Participants

Reaction Steps

Working in a manner similar to that described in Example 1, but starting with 3-hydroxy-2-(7-methyl-1,8-naphthyridin-2-yl)-1-isoindolinone (7.9 g), an oily suspension (50% by weight; 2 g) of sodium hydride and 5-methyl-2-hexanone (6.2 g), and stirring the reaction mixture for 3 hours at a temperature in the region of -5° C., and then for 2 hours at 0° C., 2-(7-methyl-1,8-naphthyridin-2-yl)-3-(5-methyl-2-oxohexyl)-1-isoindolinone (1 g), m.p. 155° C., is obtained after recrystallization in ethanol.

Provenance & Evidence