Sodium hydride → HCID 86744250, compound

Participants

Reaction Steps

Ethyl 2-[2-(7-chloro-1,8-naphthyridin-2-yl)-4-methyl-3-oxopentanoate may be prepared by working in a manner similar to that described in Example 23, but starting with ethyl 4-methyl-3-oxopentanoate (4.7 g), an oily suspension (50% by weight; 1.2 g) of sodium hydride and 3-chloro-2-(7-chloro-1,8-naphthyridin-2-yl)-1-isoindolinone (6.6 g). After recrystallization in diisopropyl ether, ethyl 2-[2-(7-chloro-1, 8-naphthyridin-2-yl)-3-oxo-1-isoindolinyl]-4-methyl-3-oxopentanoate (7 g), m.p. 146° C., is thereby obtained.

Provenance & Evidence