Hydrochloric Acid → HCID 22163914, compound

Participants

Reaction Steps

A solution of 1.0 g of N-hydroxy-1-[1-(2,6-dimethylphenyl)-1H-pyrrol-3-yl]-ethylamine in 60 ml of toluene is stirred and treated first with one mole equivalent of 4.0M ethanolic HCl, followed by 10 ml of 2.0M phosgene in toluene. The solution is stirred for 7 hours, 50 ml of concentrated ammonium hydroxide is added and the mixture is stirred overnight. Excess water is then added and the mixture is again stirred for 2 hours. The organic layer is separated, washed with brine, dried over magnesium sulfate, treated with charcoal and evaporated to dryness to yield N-carbamoyl-N-hydroxy-1-[1-(2,6-dimethylphenyl)-1H-pyrrol-3-yl]-ethylamine.

Provenance & Evidence