Tetrahydrofuran → N-[2-(Diethylamino)ethyl]-4-(2-pyridinyl)-1-piperazine carboxamide, hydrochloride

Participants

Reaction Steps

This compound was prepared according to the procedure used to synthesize the compound of Example 9. A mixture of 5.0 g (0.03 mole) of 1',1'-carbonyldiimidazole, 3.6 g (0.03 mole) of unsym-diethylethylenediamine, and 5.0 g (0.03 mole) of 1-(2-pyridinyl)piperazine in a total of 200 ml of tetrahydrofuran gave an oil as residue. The hydrochloride was formed in ethereal hydrogen chloride and the collected solid was recrystallized from methanol-ethyl ether to yield 7.3 g (63%) of title compound as a white solid, m.p. 183°-185° C.

Provenance & Evidence