N,N-Dimethylethylenediamine → 4-(4-Chlorophenyl)-N-[2-(dimethylamino)ethyl]-1-piperazinecarboxamide

Participants

Reaction Steps

This compound was prepared according to the procedure used to synthesize the compound of Example 11. A mixture of 4.9 g (0.03 mole) of 1,1'-carbonyldiimidazole, 2.6 g (0.03 mole) of unsym-dimethylethylenediamine, and 5.9 g (0.03 mole) of 1-(4-chlorophenyl)piperazine in a total of 200 ml of tetrahydrofuran gave an oil which solidified when triturated with petroleum ether (30°-60° C.). The collected solid was recrystallized from 2-propanol-isopropyl ether to yield 6.1 g (66%) of the title compound as a white, crystalline solid, m.p. 125°-128° C.

Provenance & Evidence