N,N-Dimethylethylenediamine → N-[2-(Dimethylamino)ethyl]-4-(4-methoxyphenyl)-1-piperazinecarboxamide

HRID 1087826노트

반응식

HRID 1087826 반응식
[CH3:1][N:2]([CH3:21])[CH2:3][CH2:4][NH:5][C:6]([N:8]1[CH2:13][CH2:12][N:11]([C:14]2[CH:19]=[CH:18][C:17](F)=[CH:16][CH:15]=2)[CH2:10][CH2:9]1)=[O:7].[C:22](N1C=CN=C1)(N1C=CN=C1)=[O:23].CN(CCN)C.COC1C=CC(N2CCNCC2)=CC=1>O1CCCC1>[CH3:1][N:2]([CH3:21])[CH2:3][CH2:4][NH:5][C:6]([N:8]1[CH2:13][CH2:12][N:11]([C:14]2[CH:19]=[CH:18][C:17]([O:23][CH3:22])=[CH:16][CH:15]=2)[CH2:10][CH2:9]1)=[O:7]

참가 물질

6

반응물 4

HCID 66053N,N-DimethylethylenediamineHCID 682631,1'-CarbonyldiimidazoleHCID 2697221-(4-Methoxyphenyl)piperazineHCID 14763463N-[2-(Dimethylamino)ethyl]-4-(4-fluorophenyl)-1-piperazinecarboxamide

생성물 1

HCID 14763472N-[2-(Dimethylamino)ethyl]-4-(4-methoxyphenyl)-1-piperazinecarboxamide수율 24%

시약·촉매·용매 1

HCID 8028Tetrahydrofuran용매

실험 절차

This compound was prepared according to the procedure used to synthesize the compound of Example 11. A mixture of 4.9 g (0.03 mole) of 1,1'-carbonyldiimidazole, 2.6 g (0.03 mole) of unsym-dimethylethylenediamine, and 5.8 g (0.03 mole) of 1-(4-methoxyphenyl)piperazine in a total of 200 ml of tetrahydrofuran gave an oil which solidified. After trituration with petroleum ether (30°-60° C.), the collected solid was recrystallized from cyclohexanebenzene to yield 2.2 g (24%) of the title compound as a white, crystalline solid, m.p. 79°-82° C.

후처리

  1. customThis compound was prepared
  2. customgave an oil which
  3. customAfter trituration with petroleum ether (30°-60° C.), the collected solid was recrystallized from cyclohexanebenzene

출처 및 근거

ORD 기록
ord-c723f10f89fc4f30991e4d6c323ae713
출처 데이터셋
uspto-grants-1990_10
특허 번호
US04960776

반응 노트

불러오는 중…