HuagongsheHuagongshe Chemistry Print Report · For research reference only
N,N-Dimethylethylenediamine → 4-(3,4-Dichlorophenyl)-N-[2-(dimethylamino)ethyl]-1-piperazinecarboxamide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | N,N-Dimethylethylenediamine | HCID 66053 | — |
| Reactant | 1,1'-Carbonyldiimidazole | HCID 68263 | — |
| Reactant | 1-(3,4-Dichlorophenyl)piperazine | HCID 93601 | — |
| Reactant | N-[2-(Dimethylamino)ethyl]-4-(4-fluorophenyl)-1-piperazinecarboxamide | HCID 14763463 | — |
| Solvent | Tetrahydrofuran | HCID 8028 | — |
| Product | 4-(3,4-Dichlorophenyl)-N-[2-(dimethylamino)ethyl]-1-piperazinecarboxamide | HCID 14763486 | — |
Reaction Steps
This compound was prepared according to the procedure used to synthesize the compound of Example 11. A mixture of 2.5 g (0.025 mole) of 1,1'-carbonyldiimidazole, 1.4 g (0.015 mole) of unsym-dimethylethylenediamine and 3.6 g (0.015 mole) of 1-(3,4-dichlorophenyl)piperazine in a total of 100 ml of tetrahydrofuran gave an oil which solidified when triturated with cyclohexane. White solid, the title compound, in the amount of 4.0 g (75%) was collected, m.p. 80°-83° C.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04960776 |
| Source dataset | uspto-grants-1990_10 |
| ORD ID | ord-825f4b0ba7684fc7bde3a17d439c4288 |
| Source note | uspto-grants-1990_10 |