HuagongsheHuagongshe Chemistry Print Report · For research reference only
Hydrochloric Acid → HCID 14763459, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Hydrochloric Acid | HCID 313 | — |
| Reactant | N,N-Dimethylethylenediamine | HCID 66053 | — |
| Reactant | 1,1'-Carbonyldiimidazole | HCID 68263 | — |
| Reactant | 1-(2-Fluorophenyl)piperazine | HCID 70529 | — |
| Reactant | N-[2-(Dimethylamino)ethyl]-4-(4-fluorophenyl)-1-piperazinecarboxamide | HCID 14763463 | — |
| Solvent | Tetrahydrofuran | HCID 8028 | — |
| Product | HCID 14763459 | HCID 14763459 | — |
Reaction Steps
This compound was prepared according to the procedure used to synthesize the compound of Example 11. A mixture of 2.2 g (0.01 mole) of 1,1'-carbonyldiimidazole, 2.2 g (0.01 mole) of unsym-dimethylethylenediamine and 2.5 g (0.01 mole of 1-(2-fluorophenyl)piperazine in a total volume of 100 ml of tetrahydrofuran gave an oil as residue. The hydrochloride was formed in ethereal hydrogen chloride and the solid recrystallized from methanol-diethyl ether to give 2.3 g (46%) of title compound as a white solid, m.p. 153°-155° C.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04960776 |
| Source dataset | uspto-grants-1990_10 |
| ORD ID | ord-99d029e3cafb4fe8afcaf9f946dc2c96 |
| Source note | uspto-grants-1990_10 |