Methyl iodide → HCID 19867845, compound

HRID 1087856Notes

Reaction equation

HRID 1087856 reaction equation
[CH3:1][O:2][C:3]1[C:8]([O:9][CH3:10])=[CH:7][C:6]([CH2:11][CH2:12][N:13]([CH3:15])[CH3:14])=[C:5]([C:16]#[C:17][C:18]2[CH:23]=[CH:22][CH:21]=[CH:20][CH:19]=2)[CH:4]=1.[CH3:24][I:25]>C(O)C>[OH2:2].[I-:25].[CH3:1][O:2][C:3]1[C:8]([O:9][CH3:10])=[CH:7][C:6]([CH2:11][CH2:12][N+:13]([CH3:24])([CH3:14])[CH3:15])=[C:5]([C:16]#[C:17][C:18]2[CH:19]=[CH:20][CH:21]=[CH:22][CH:23]=2)[CH:4]=1

Participants

4

Reactant 2

HCID 6328Methyl iodideHCID 14879038HCID 14879038, compound

Product 1

HCID 19867845HCID 19867845, compoundYield 112.8%

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

To a solution of 5.28 g (0.017 mole) of 4,5-dimethoxy-N,N-dimethyl-2-(phenylethynyl) benzeneethanamine in 20 ml of ethanol was added 1.43 ml (0.023 mole) of methyl iodide. The solid was collected and recrystallized successively from ethanol and methanol to afford 4.5 g of white crystalline 4,5-dimethoxy-N,N,N-trimethyl-2-(phenylethynyl) benzeneethanaminium iodide hydrate (2:2:1), mp 134°-150° C., yield 58%.

Workup

  1. customThe solid was collected
  2. customrecrystallized successively from ethanol and methanol

Sources & evidence

ORD record
ord-9596f87099cf4801ad74cd54fc9e59e4
Source dataset
uspto-grants-1990_10
Patent number
US04960798

Reaction notes

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