HCID 53951174, compound → HCID 54171784, compound

HRID 1087867Notes

Reaction equation

HRID 1087867 reaction equation
[CH3:1][O:2][C:3]([C:5]1[N:6]=[CH:7][C:8]2[NH:9][C:10]3[C:15]([C:16]=2[CH:17]=1)=[CH:14][C:13]([O:18][C:19]1[CH:24]=[CH:23][C:22]([N+:25]([O-])=O)=[CH:21][N:20]=1)=[CH:12][CH:11]=3)=[O:4]>CO.[Pd]>[CH3:1][O:2][C:3]([C:5]1[N:6]=[CH:7][C:8]2[NH:9][C:10]3[C:15]([C:16]=2[CH:17]=1)=[CH:14][C:13]([O:18][C:19]1[CH:24]=[CH:23][C:22]([NH2:25])=[CH:21][N:20]=1)=[CH:12][CH:11]=3)=[O:4]

Participants

4

Reactant 1

HCID 53951174HCID 53951174, compound

Product 1

HCID 54171784HCID 54171784, compound

Reagents, catalysts & solvents 2

HCID 23938PalladiumCatalystHCID 887MethanolSolvent

Procedure

A suspension of 3.65 g of 6-(5-nitro-2-pyridyloxy)-β-carboline-3-carboxylic acid methyl ester and 0.5 g of Pd-C (10%) in 100 ml of methanol is hydrogenated at room temperature and under normal pressure. After absorption of the stoichiometric amount of hydrogen, the mixture is filtered and concentrated. The residue is crystallized from methanol/diethyl ether, yielding 2.84 g (85%).

Workup

  1. customis hydrogenated at room temperature and under normal pressure
  2. customAfter absorption of the stoichiometric amount of hydrogen
  3. filtrationthe mixture is filtered
  4. concentrationconcentrated
  5. customThe residue is crystallized from methanol/diethyl ether
  6. customyielding 2.84 g (85%)

Sources & evidence

ORD record
ord-9cdbc80776594e5b9384a7cc803c7fd4
Source dataset
uspto-grants-1990_10
Patent number
US04960777

Reaction notes

Loading…