Phosphorus tribromide → HCID 22164149, compound

Participants

Reaction Steps

In a manner similar to that described by Noller et al. (Organic Synthesis, Vol. II. p 358-360), 2.0 grams (0.086 mole) of 1,2-di(2-fluoroethoxy)-3-hydroxymethylbenzene and 1.1 ml (0.0032 mole) of phosphorus tribromide were reacted in 90 ml of cold (0° C.) diethyl ether. The reaction mixture was partitioned between water and diethyl ether. The organic phase was washed with an aqueous, saturated sodium chloride solution. The washed organic phase was dried over anhydrous magnesium sulfate and filtered. The filtrate was evaporated under reduced pressure to yield 2.3 grams of 3-bromomethyl-1,2-di(2fluoroethoxy)benzene as a solid, mp 99°-100° C.

Provenance & Evidence