Sulfuric Acid → HCID 15058793, compound

HRID 1087903Notes

Reaction equation

HRID 1087903 reaction equation
[CH:1]([OH:14])([C:8]1[CH:13]=[CH:12][CH:11]=[CH:10][CH:9]=1)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[F:15][CH2:16][CH2:17]O.S(=O)(=O)(O)O>C(OCC)C>[C:2]1([CH:1]([O:14][CH2:17][CH2:16][F:15])[C:8]2[CH:9]=[CH:10][CH:11]=[CH:12][CH:13]=2)[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1

Participants

5

Reactant 3

HCID 1118Sulfuric AcidHCID 7037BenzhydrolHCID 97372-Fluoroethanol

Product 1

HCID 15058793HCID 15058793, compoundYield 79%

Reagents, catalysts & solvents 1

HCID 3283Diethyl EtherSolvent

Procedure

To a stirred solution of 2.0 grams (0.011 mole) of benzhydrol in 15 ml of diethyl ether was added 4.0 ml (0.068 mole) of 2-fluoroethanol followed by the dropwise addition of 0.5 ml of concentrated sulfuric acid. The reaction mixture was stirred at room temperature for 24 hours. The reaction mixture was extracted with diethyl ether. The organic extract was washed with water followed by an aqueous, saturated sodium bicarbonate solution. The washed extract was dried over anhydrous magnesium sulfate and filtered. The filtrate was evaporated under reduced pressure to yield 2.0 grams of 2-fluoroethyl diphenylmethyl ether as a liquid.

Workup

  1. extractionThe reaction mixture was extracted with diethyl ether
  2. extractionThe organic extract
  3. washwas washed with water
  4. extractionThe washed extract
  5. dry with materialwas dried over anhydrous magnesium sulfate
  6. filtrationfiltered
  7. customThe filtrate was evaporated under reduced pressure

Sources & evidence

ORD record
ord-b7eb8695212640abb809b0b92a66e098
Source dataset
uspto-grants-1990_10
Patent number
US04960884

Reaction notes

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