2-Butene, 1-bromo-3-methyl- → HCID 15030193, compound

HRID 1087911Notes

Reaction equation

Br[CH2:2][CH:3]=[C:4]([CH3:6])[CH3:5].[OH:7][C:8]1[CH:9]=[C:10]2[C:15](=[CH:16][CH:17]=1)[CH:14]=[C:13]([CH:18]([CH3:22])[C:19]([OH:21])=[O:20])[CH:12]=[CH:11]2>>[CH3:22][CH:18]([C:13]1[CH:12]=[CH:11][C:10]2[C:15](=[CH:16][CH:17]=[C:8]([O:7][CH2:2][CH:3]=[C:4]([CH3:6])[CH3:5])[CH:9]=2)[CH:14]=1)[C:19]([OH:21])=[O:20]

Participants

Reactant 2

HCID 700922-Butene, 1-bromo-3-methyl-

HCID 162920Desmethylnaproxen

Product 1

HCID 15030193HCID 15030193, compound

Procedure

The title compound is prepared according to the method of Example 7 using 1-bromo-3-methyl-2-butene and racemic 6-hydroxy-α-methyl-2-naphthalene acetic acid. White crystals are obtained having a melting point of 97°-100° C.

Workup

customWhite crystals are obtained

Sources & evidence

ORD record: ord-163e34dbfd8d4577b09190173275cddd
Source dataset: uspto-grants-1990_10
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US04960892

Reaction notes

Loading…