反应详情

温度

80 °C

A mixture of 7.12 g of 3-bromo-5-isopropenylpyridine, 6.85 g of N-chlorosuccinimide and 15 ml of carbon tetrachloride was stirred at 80° C. for 7 hours. After the reaction mixture was cooled to room temperature, the insoluble matter was filtered out. The filtrate was concentrated under a reduced pressure and the residue was purified by silica gel column chromatography (eluted with ethyl acetate-n-hexane 1:19) to obtain 2.23 g of the objective compound.

1. temperatureAfter the reaction mixture was cooled to room temperature
2. filtrationthe insoluble matter was filtered out
3. concentrationThe filtrate was concentrated under a reduced pressure
4. customthe residue was purified by silica gel column chromatography (eluted with ethyl acetate-n-hexane 1:19)