Tetrahydrofuran → HCID 22164489, compound

Participants

Reaction Steps

A 10 1 magnetic lift stirred autoclave is charged with 1,015 g of 2,3,3-trimethoxyprop-1-ene together with 3,000 g of tetrahydrofuran and 500 mg of Rh2 (COD)2Cl2 as hydroformylation catalyst. The oxo reaction is carried out under a pressure of 500 bar (CO/H2 =1:1) at 40° C. for 6 hours, at 60° C./550 bar for another 6 hours and at 80° C./600 bar for a further 6 hours. According to gas chromatography, this way of carrying out the reaction gives a conversion of 94%. The desired compound 3,4,4-trimethoxybutanal (bp=135° C./110 mbar) is obtained in the yield of 87% following fraction-ation. Preparation of methyl 2-methoxyacrylate

Provenance & Evidence