Acetic Acid → HCID 131716592, compound

Participants

Reaction Steps

This product (b) (2.1 g; 3.69 millimoles) is dissolved in tetrahydrofuran (10 ml), mixed with acetic acid (0.8 ml) and tetrabutylammonium fluoride trihydrate (2.78 g; 2.4 equivalents) and kept at room temperature for two nights as in Example B'-12 to give 6α-(1-hydroxyethyl)-1-methyl-2-(4-pyridylthio)methylidene-1-carbapenam-3-carboxylic acid p-methoxybenzyl ester (100 mg; Yield: 6.0%, from less polar fraction) and 6α-(1-hydroxyethyl)-1-methyl-2-(4-pyridylthio)methyl-1-carbapen-2-em-3-carboxylic acid p-methoxybenzyl ester (b) (455 mg; Yield: 27.1%; having physical constants as follows from polar fraction).

Provenance & Evidence