Sodium Iodide → HCID 178480376, 화합물

HRID 1088037노트

반응식

HRID 1088037 반응식
[I-:1].[Na+].[C:3]([O:7][C:8]([NH:10][C@@H:11]1[C:36](=[O:37])[N:13]2[C:14]([C:20]([O:22][CH:23]([C:30]3[CH:35]=[CH:34][CH:33]=[CH:32][CH:31]=3)[C:24]3[CH:29]=[CH:28][CH:27]=[CH:26][CH:25]=3)=[O:21])=[C:15]([CH2:18]Cl)[CH2:16][S:17][C@H:12]12)=[O:9])([CH3:6])([CH3:5])[CH3:4].[CH3:38][N:39]1[CH:43]=[CH:42][CH:41]=[N:40]1.O1CCCC1>CC(C)=O.O.C(OCC)(=O)C>[I-:1].[C:3]([O:7][C:8]([NH:10][C@@H:11]1[C:36](=[O:37])[N:13]2[C:14]([C:20]([O:22][CH:23]([C:30]3[CH:35]=[CH:34][CH:33]=[CH:32][CH:31]=3)[C:24]3[CH:29]=[CH:28][CH:27]=[CH:26][CH:25]=3)=[O:21])=[C:15]([CH2:18][N+:40]3[N:39]([CH3:38])[CH:43]=[CH:42][CH:41]=3)[CH2:16][S:17][C@H:12]12)=[O:9])([CH3:6])([CH3:5])[CH3:4]

참가 물질

8

반응물 4

HCID 5238Sodium IodideHCID 8028TetrahydrofuranHCID 702551H-Pyrazole, 1-methyl-HCID 11756232(6R,7R)-Benzhydryl 7-((tert-butoxycarbonyl)amino)-3-(chloromethyl)-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylate

생성물 1

HCID 178480376HCID 178480376, 화합물

시약·촉매·용매 3

HCID 180Acetone용매HCID 962Water용매HCID 8857Ethyl Acetate용매

실험 절차

To a solution of sodium iodide (1.46 g) in acetone (5 ml) was added benzhydryl 7β-tert-butoxycarbonylamino-3-chloromethyl-3-cephem-4-carboxylate (5 g) at ambient temperature. The mixture was stirred at the same temperature for 10 minutes and N-methylpyrazole (5 ml) was added thereto. The resultant mixture was stirred at the same temperature for 24 hours and poured into a mixture of tetrahydrofuran (25 ml), ethyl acetate (25 ml) and water (25 ml). The separated organic layer was washed with brine, and dried over magnesium sulfate. The solution was evaporated in vacuo to give benzhydryl 7β-tert-butoxycarbonylamino-3-(2-methyl-1-pyrazolio)methyl-3-cephem-4-carboxylate iodide (6.45 g), the physical data of which were identical to those of the compound prepared in Preparation 3.

후처리

  1. washThe separated organic layer was washed with brine
  2. dry with materialdried over magnesium sulfate
  3. customThe solution was evaporated in vacuo

출처 및 근거

ORD 기록
ord-cfb8c45eb82741aa8f4a854fddd65083
출처 데이터셋
uspto-grants-1990_10
특허 번호
US04960766

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