Sodium Acetate → HCID 73653992, compound

HRID 1088098Notes

Reaction equation

HRID 1088098 reaction equation
[Cl:1][C:2]([Cl:21])([Cl:20])[CH2:3][O:4][C:5]([CH2:7][O:8][N:9]=[C:10]([C:16](=O)[CH2:17]Cl)[C:11]([O:13][CH2:14][CH3:15])=[O:12])=[O:6].[NH2:22][C:23]([NH2:25])=[S:24].C([O-])(=O)C.[Na+]>C(O)C.O>[NH2:25][C:23]1[S:24][CH:17]=[C:16]([C:10](=[N:9][O:8][CH2:7][C:5]([O:4][CH2:3][C:2]([Cl:21])([Cl:20])[Cl:1])=[O:6])[C:11]([O:13][CH2:14][CH3:15])=[O:12])[N:22]=1

Participants

6

Reactant 3

HCID 517045Sodium AcetateHCID 2723790ThioureaHCID 54145401HCID 54145401, compound

Product 1

HCID 73653992HCID 73653992, compoundYield 51.1%

Reagents, catalysts & solvents 2

HCID 702EthanolSolventHCID 962WaterSolvent

Conditions

Temperature
40 °C

Procedure

A mixture of ethyl 2-(2,2,2-trichloroethoxycarbonylmethoxyimino)-4-chloro-3-oxobutyrate (20 g), thiourea (3.9 g) and sodium acetate (4.2 g) in ethanol (50 ml) and water (50 ml) was stirred at 40° C. for 5 hours. After removal of the solvent from the reaction mixture, the residue was triturated with diisopropyl ether. The precipitates were collected by filtration and washed with diisopropyl ether to give ethyl 2-(2-aminothiazol-4-yl)-2-(2,2,2-trichloroethoxycarbonylmethoxyimino)acetate (syn isomer) (10.6 g), mp 138°-141° C.

Workup

  1. customAfter removal of the solvent from the reaction mixture
  2. customthe residue was triturated with diisopropyl ether
  3. filtrationThe precipitates were collected by filtration
  4. washwashed with diisopropyl ether

Sources & evidence

ORD record
ord-c4efd99e4bbc4a2db9e74b91b26a687b
Source dataset
uspto-grants-1990_10
Patent number
US04960889

Reaction notes

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