Ici 109,081 → HCID 178429567, compound

Participants

Reaction Steps

A stirred mixture of 6-(4-aminophenyl)-5-methyl-4,5-dihydro-3(2H)-pyridazinone (2 g) and 2-methylthio-4-quinazolinone (2.98 g) in dry pyridine (15 ml) was heated under reflux for 90 hours. The mixture was filtered and the solid digested with boiling acetonitrite to leave a solid (0.66 g), m.p. 313°-319° C. The combined filtrates were evaporated and the residue was heated with pyridine (3 ml) in the absence of a condenser, in an oil bath at 160° C. for 3 hours. The residue was digested with acetonitrile as before to give the title compound, (0.55 g), m.p. 312°-315° C.

Provenance & Evidence