2-(Methylthio)-1H-pyrimidin-4-one → HCID 178461473, compound

HRID 1088219Notes

Reaction equation

HRID 1088219 reaction equation
[NH2:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]2[C@H:9]([CH3:15])[CH2:10][C:11](=[O:14])[NH:12][N:13]=2)=[CH:4][CH:3]=1.CS[C:18]1[NH:24][C:22](=[O:23])[CH:21]=[CH:20][N:19]=1>N1C=CC=CC=1>[O:23]=[C:22]1[CH:21]=[CH:20][NH:19][C:18]([NH:1][C:2]2[CH:7]=[CH:6][C:5]([C:8]3[C@H:9]([CH3:15])[CH2:10][C:11](=[O:14])[NH:12][N:13]=3)=[CH:4][CH:3]=2)=[N:24]1

Participants

4

Reactant 2

HCID 798232-(Methylthio)-1H-pyrimidin-4-oneHCID 10465484(R)-6-(4-Aminophenyl)-5-methyl-4,5-dihydropyridazin-3(2H)-one

Product 1

HCID 178461473HCID 178461473, compound

Reagents, catalysts & solvents 1

HCID 1049PyridineSolvent

Procedure

A stirred mixture of (R)-6-(4-aminophenyl)-5-methyl-4,5-dihydro-3(2H)-pyridazinone and 2-methylthiouracil in dry pyridine are heated together to afford the title compound.

Workup

  1. temperatureare heated together

Sources & evidence

ORD record
ord-ff595e8578ba4c7aad1d959de9f765c7
Source dataset
uspto-grants-1990_10
Patent number
US04962110

Reaction notes

Loading…