2-(Methylthio)-1H-pyrimidin-4-one → HCID 178471508, compound

HRID 1088220Notes

Reaction equation

HRID 1088220 reaction equation
[NH2:1][C:2]1[CH:17]=[CH:16][C:5]([C:6]([CH:8]([CH3:15])[CH2:9][C:10]([O:12][CH2:13][CH3:14])=[O:11])=[O:7])=[CH:4][CH:3]=1.CS[C:20]1[NH:26][C:24](=[O:25])[CH:23]=[CH:22][N:21]=1>N1C=CC=CC=1>[O:25]=[C:24]1[CH:23]=[CH:22][NH:21][C:20]([NH:1][C:2]2[CH:3]=[CH:4][C:5]([C:6]([CH:8]([CH3:15])[CH2:9][C:10]([O:12][CH2:13][CH3:14])=[O:11])=[O:7])=[CH:16][CH:17]=2)=[N:26]1

Participants

4

Reactant 2

HCID 798232-(Methylthio)-1H-pyrimidin-4-oneHCID 15717867Ethyl 4-(4-aminophenyl)-3-methyl-4-oxobutanoate

Product 1

HCID 178471508HCID 178471508, compound

Reagents, catalysts & solvents 1

HCID 1049PyridineSolvent

Procedure

A stirred mixture of ethyl 3-(4-aminobenzoyl)butyrate and 2-methylthiouracil in dry pyridine are heated together to afford the title compound.

Workup

  1. temperatureare heated together

Sources & evidence

ORD record
ord-54daeb599da143ec9bd8430ef6f2eee1
Source dataset
uspto-grants-1990_10
Patent number
US04962110

Reaction notes

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