HuagongsheHuagongshe Chemistry Print Report · For research reference only
4-Aminopyridine → 1-(2,6-Dichlorophenyl)-3-(4-pyridyl)urea
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 4-Aminopyridine | HCID 1727 | — |
| Reactant | 1,3-Dichloro-2-isocyanatobenzene | HCID 604537 | — |
| Solvent | Tetrahydrofuran | HCID 8028 | — |
| Product | 1-(2,6-Dichlorophenyl)-3-(4-pyridyl)urea | HCID 4610560 | — |
Reaction Steps
A solution of 4.7 g (0.05 mole) of 4-aminopyridine in 300 ml of anhydrous tetrahydrofuran was treated with 9.4 g (0.05 mole) of 2,6-dichlorophenylisocyanate. The solution was heated at reflux for 24 hours, cooled, and concentrated in vacuo to a solid. Recrystallization from aqueous ethanol afforded the crystalline product, mp 217°-219° C.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04962116 |
| Source dataset | uspto-grants-1990_10 |
| ORD ID | ord-691812531a984a799cface0b51b3898a |
| Source note | uspto-grants-1990_10 |