Imidazole → HCID 15671472, compound

Participants

Reaction Steps

(2S,4R)-1-(p-Nitrobenzyloxycarbonyl)-2-hydroxymethyl-4-benzoyloxypyrrolidine (1.09 g), imidazole (0.46 g) and t-butyldimethylsilyl chloride (0.49 g) were dissolved in 16.5 ml of dry dimethylformamide. The resulting mixture was stirred at room temperature for 2 hours, diluted with ethyl acetate, washed with water, dried over anhydrous magnesium sulfate and distilled to remove the solvent. The residue was purified by silica gel chromatography to obtain (2S,4R)-1-(p-nitrobenzyloxycarbonyl)-2-t-butyldimethylsilyloxymethyl-4-benzoyloxypyrrolidine.

Provenance & Evidence