Lithium iodide → HCID 15671481, compound

Participants

Reaction Steps

trans-1-(p-Methoxybenzyloxycarbonyl)-4-t-butyldimethylsilyloxy-L-proline methyl ester (5.64 g) was dissolved in 56.4 ml of dry tetrahydrofuran. Sodium borohydride (1.01 g) and lithium iodide (3.52 g) were added thereto. The resulting mixture was refluxed for 1 hour, diluted with water, extracted with ethyl acetate, washed with water, dried over anhydrous sodium sulfate and distilled off to obtain (2S,4R)-1-(p-methoxybenzyloxycarbonyl)-2-hydroxymethyl-4-t-butyldimethylsilyloxypyrrolidine.

Provenance & Evidence