HCID 15671515, compound → HCID 15671516, compound

Participants

Reaction Steps

(2R,4R)-1-Benzyloxycarbonyl-2-(3-cyanopropyl)-4-t-butyldimethylsilyloxypyrrolidine (1.69 g) was dissolved in 34 ml of ethanol, and 338 mg of 5% palladium-carbon was added thereto, followed by hydrogenation at room temparature under 1 atm. for 2 hours. The catalyst was removed by filtration, and the filtrate was distilled to obtain (2R,4R)-2-(3-cyanopropyl)-4-t-butyldimethylsilyloxypyrrolidine.

Provenance & Evidence