Methanol → HCID 56619902, compound

Participants

Reaction Steps

(2R,4R)-1-p-Nitrobenzyloxycarbonyl-2-carboxymethyl-4-hydroxypyrrolidine (5.39 g) was dissolved in 54 ml of dry methanol, and 0.9 ml of conc. sulfuric acid was added thereto, followed by refluxing for 4 hours. The reaction mixture was neutralized with 1N sodium hydroxide solution and distilled to remove the solvent. To the residue was added ethyl acetate, and the mixture was washed with water, dried over anhydrous sodium sulfate and distilled to obtain (2S,4R)-1-p-nitrobenzyloxycarbonyl-2-methoxycarbonylmethyl-4-hydroxypyrrolidine.

Provenance & Evidence