Acetic Anhydride → HCID 15671530, compound

Participants

Reaction Steps

(2R,4R)-1-p-Nitrobenzyloxycarbonyl-2-(2-hydroxyethyl)-4-t-butyldimethylsilyloxypyrrolidine (900 mg) was dissolved in 2.25 ml of dry pyridine, and 2.25 ml of acetic anhydride was added to the solution at room temperature, followed by stirring for 1 hour. The reaction mixture was diluted with diethyl ether, washed successively with brine, a diluted aqueous hydrochloric acid, brine, a diluted aqueous sodium hydroxide solution and brine, dired over anhydrous sodium sulfate to give (2R,4R)-1-p-nitrobenzyloxycarbonyl-2-(2-acetoxyethyl)-4-t-butyldimethylsilyloxypyrrolidine.

Provenance & Evidence