化工社化工社 化学情報印刷レポート · 研究参考用
N-(1,1-Dimethylethyl)-1,3-propanediamine → N-[3-[(1,1-Dimethylethyl)amino]propyl]-4,5-diphenyl-1H-imidazole-1-acetamide
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | N-(1,1-Dimethylethyl)-1,3-propanediamine | HCID 40274 | — |
| 反応物 | 3-(tert-BUTYLAMINO)PROPIONITRILE | HCID 2757246 | — |
| 反応物 | Ethyl 4,5-diphenyl-1H-imidazole-1-acetate | HCID 14820171 | — |
| 反応物 | Aluminium lithium hydride | HCID 21226445 | — |
| 溶媒 | Water | HCID 962 | — |
| 溶媒 | Dichloromethane | HCID 6344 | — |
| 溶媒 | Tetrahydrofuran | HCID 8028 | — |
| 生成物 | N-[3-[(1,1-Dimethylethyl)amino]propyl]-4,5-diphenyl-1H-imidazole-1-acetamide | HCID 14820174 | 50.1% |
反応条件
| 温度 | 100 °C |
|---|
反応手順
A mixture of 7.0 g (23 mmol) of ethyl 4,5-diphenyl-1H-imidazole-1-acetate of example 1 and 4.5 g (34.6 mmol) of 3-(t-butylamino)propylamine, conveniently made by LAH reduction of 3-(t-butylamino)propionitrile in THF, was heated at 100° C. for 8 hr. The residue was distributed between water and methylene chloride, and the methylene chloride layer was dried over MgSO4 and stripped. The residue was recrystallized from ether and then cyclohexane to yield 4.5 g of product, mp 94°-96° C.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US04962120 |
| 出典データセット | uspto-grants-1990_10 |
| ORD ID | ord-c994c8e965704442a0afefbd84abbe5a |
| 出典メモ | uspto-grants-1990_10 |