Benzenesulfonic acid, 4-methyl-, compd. with pyridine (1:1) → Methyl 2-(5-bromo-1,3-dioxo-1,3-dihydro-isoindol-2-ylmethyl)-3-oxo-butyrate

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Reaction Steps

Methyl 2-(5-bromo-1,3-dioxo-1,3-dihydro-isoindol-2-ylmethyl)-3-oxo-butyrate was prepared (106 mg, 24%) in the same manner as described in the above example 6 (1) from methyl 3-(5-bromo-1,3-dioxo-1,3-dihydro-isoindol-2-yl)-2-(2-methyl-[1,3]dioxolan-2-yl)propionate (0.46 g, 1.14 mmol) and pyridinium p-toluenesulfonate (50 mg), and the obtained product was identified with the following NMR data.

Provenance & Evidence