Water → 3,3-bis(4-fluorophenyl)tetrahydro-2H-pyran-2-one

HRID 1088332Notes

Reaction equation

HRID 1088332 reaction equation
Cl[CH2:2][CH2:3][CH2:4][C:5]([C:15]1[CH:20]=[CH:19][C:18]([F:21])=[CH:17][CH:16]=1)([C:8]1[CH:13]=[CH:12][C:11]([F:14])=[CH:10][CH:9]=1)[C:6]#N.S(=O)(=O)(O)[OH:23].[OH2:27]>C(O)(=O)C>[F:14][C:11]1[CH:12]=[CH:13][C:8]([C:5]2([C:15]3[CH:20]=[CH:19][C:18]([F:21])=[CH:17][CH:16]=3)[CH2:4][CH2:3][CH2:2][O:27][C:6]2=[O:23])=[CH:9][CH:10]=1

Participants

5

Reactant 3

HCID 962WaterHCID 1118Sulfuric AcidHCID 19883501alpha-(3-Chloropropyl)-4-fluoro-alpha-(4-fluorophenyl)benzeneacetonitrile

Product 1

HCID 142302603,3-bis(4-fluorophenyl)tetrahydro-2H-pyran-2-one

Reagents, catalysts & solvents 1

HCID 176Acetic AcidSolvent

Procedure

A mixture of 3 parts of α-(3-chloropropyl)-4-fluoro-α-(4-fluorophenyl)benzeneacetonitrile, 92 parts of concentrated sulfuric acid, 50 parts of water and 50 parts of acetic acid was stirred and refluxed for 24 hours. The reaction mixture was concentrated to about 100 parts and the product was extracted with methylbenzene. The extract was washed with water, dried, filtered and evaporated. The residue was suspended in petroleum ether. The product was filtered off and crystallized from 2,2'-oxybispropane, yielding 1.41 parts of 3,3-bis(4-fluorophenyl)tetrahydro-2H-pyran-2-one; mp. 122.4° C. (intermediate 21).

Workup

  1. temperaturerefluxed for 24 hours
  2. concentrationThe reaction mixture was concentrated to about 100 parts
  3. extractionthe product was extracted with methylbenzene
  4. washThe extract was washed with water
  5. customdried
  6. filtrationfiltered
  7. customevaporated
  8. filtrationThe product was filtered off
  9. customcrystallized from 2,2'-oxybispropane

Sources & evidence

ORD record
ord-24051c8df05c43e1a3dc2de64ee92556
Source dataset
uspto-grants-1990_10
Patent number
US04962115

Reaction notes

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