Hydrochloric Acid → HCID 67933391, compound

Participants

Reaction Steps

U.S. Patent 2,547,712 describes a process for producing certain 1-[2-furyl]-2-aminopropane diols. In a more relevant disclosure, in Example 2 of the '712 patent, the compound 2-furyl aminomethyl ketone hydrochloride is produced by reacting a 2-furyl bromomethyl ketone hexamethylene tetraamine complex with HCl. In the next step the 2-furyl aminomethyl ketone is added to a mixture of glacial acetic acid and acetic anhydride to which is then added sodium acetate. The product of that reaction is 2-furyl acetamidomethyl ketone, which is reacted with formalin, sodium bicarbonate and methanol to form 2-furyl-α-acetamido-β-hydroxyethyl ketone. This product was then reduced to the corresponding diol with aluminum isopropoxide (the catalyst of the '913 patent) in isopropanol.

Provenance & Evidence