Acetonitrile → HCID 53923850, compound

HRID 1088462Notes

Reaction equation

HRID 1088462 reaction equation
[Cl:1][C:2]1[CH:11]=[C:10]2[C:5]([CH:6]=[CH:7][C:8]([CH:12]=[CH:13][C:14]3[CH:15]=[C:16]([CH:23]=[CH:24][CH:25]=3)[O:17][CH:18]([CH3:22])[C:19]([NH2:21])=O)=[N:9]2)=[CH:4][CH:3]=1.C(#N)C>ClCCl>[Cl:1][C:2]1[CH:11]=[C:10]2[C:5]([CH:6]=[CH:7][C:8]([CH:12]=[CH:13][C:14]3[CH:15]=[C:16]([CH:23]=[CH:24][CH:25]=3)[O:17][CH:18]([CH3:22])[C:19]#[N:21])=[N:9]2)=[CH:4][CH:3]=1

Participants

4

Reactant 2

HCID 6342AcetonitrileHCID 54202893HCID 54202893, compound

Product 1

HCID 53923850HCID 53923850, compound

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

Using (+)-2-(3-(2-(7-Chloroquinolin-2-yl)ethenyl)phenoxy)propanoamide from Example 75 in place of the (+)-enantiomer in example 76, gave the title compound, mp 147°-149° C. (ex acetonitrile), D -134.4° (c 0.98 in dichloromethane).

Sources & evidence

ORD record
ord-59d151fe779744b3ad1acaae036e612b
Source dataset
uspto-grants-1990_10
Patent number
US04962203

Reaction notes

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